Investigators from the International Center for Biomedicine and the University of Chile, in collaboration with the Center for Bioinformatics of the Universidad de Talca, have discovered that two drugs, the benzimidazole derivatives lanzoprazole and astemizole, may be suitable for use as PET (positron emission tomography) radiotracers and enable imaging for the early detection of Alzheimer’s Disease. The study is published in the current issue of the Journal of Alzheimer’s Disease… (Source: Health News from Medical News Today)

Investigators from the International Center for Biomedicine and the University of Chile, in collaboration with the Center for Bioinformatics of the Universidad de Talca, have discovered that two drugs, the benzimidazole derivatives lanzoprazole and astemizole, may be suitable for use as PET (positron emission tomography) radiotracers and enable imaging for the early detection o… (Source: Alzheimer’s / Dementia News From Medical News Today)

IEEE/ACM Transactions on Computational Biology and Bioinformatics (Source: IEEE/ACM Transactions on Computational Biology and Bioinformatics)

(IOS Press) Investigators from the International Center for Biomedicine and the University of Chile, in collaboration with the Center for Bioinformatics of the Universidad de Talca, have discovered that two drugs, the benzimidazole derivatives lanzoprazole and astemizole, may be suitable for use as PET (positron emission tomography) radiotracers and enable imaging for the early detection of Alzheimer’s Disease. The study is published in the current issue of the Journal of Alzheimer’s Disease. (Source: EurekAlert! – Medicine and Health)

(Ludwig Institute for Cancer Research) Researchers in the Molecular Modeling group at the SIB Swiss Institute of Bioinformatics and Dr. Benoît J. Van den Eynde’s group at the Ludwig Institute for Cancer Research Ltd Brussels Branch developed an approach for creating new IDO inhibitors by computer-assisted structure-based drug design. The study was presented in the January 2010 online issue of the Journal of Medicinal Chemistry. (Source: EurekAlert! – Medicine and Health)

Conclusions:
MLPAinter visualises MLPA data in plots with information about sample replicates, normalisation settings, and sample characteristics. This integrated approach helps in the automated handling of large series of MLPA data and guarantees a quick and streamlined dataflow from the beginning of an experiment to an authorised report. (Source: BMC Bioinformatics – Latest articles)div id=medwormpbiMedWorm Message:/i/b Get the very latest Swine Flu news via the MedWorm ba href=http://www.medworm.com/rss/search.php?qu=%2Bswine+%2B%28influenza+flu%29t=Swine+Fluf=infectiousdiseasesr=Anyo=d target =_selfSwine Flu RSS news feed/a/b – updated hourly from thousands of authoritative health and news sources./p/div

Nature Methods 7, 98 (2010). doi:10.1038/nmeth0210-98

Author: Natalie de Souza
Annotation of clinical databases using controlled vocabulary permits cross-species comparisons of phenotypes associated with human disease. (Source: Nature Methods)

Conclusions:
We have presented a novel scoring function which can distinguish not only HP/MP ortholog pairs, but also non-homologous pairs at high accuracies. Most importantly, it can be used to accurately predict the relative stability of proteins and their mutants, as demonstrated in two blind tests. In addition, the residue substitution preference matrix assembled in this study may reflect the thermal adaptation induced substitution biases. A web server implementing the scoring function and the dataset used in this study are freely available at http://www.abl.ku.edu/thermorank/. (Source: BMC Bioinformatics – Latest articles)

Conclusions:
BIANA’s approach to data unification solves many of the nomenclature issues common to systems dealing with biological data. BIANA can easily be extended to handle new specific data repositories and new specific data types. The unification protocol allows BIANA to be a flexible tool suitable for different user requirements: non-expert users can use a suggested unification protocol while expert users can define their own specific unification rules. (Source: BMC Bioinformatics – Latest articles)